plt.close('all')
fig = plt.figure()

ax1 = plt.subplot2grid((3, 3), (0, 0))
ax2 = plt.subplot2grid((3, 3), (0, 1), colspan=2)
ax3 = plt.subplot2grid((3, 3), (1, 0), colspan=2, rowspan=2)
ax4 = plt.subplot2grid((3, 3), (1, 2), rowspan=2)

example_plot(ax1)
example_plot(ax2)
example_plot(ax3)
example_plot(ax4)

plt.tight_layout()